Database system
切换到图谱视图酶反应数据库检索（支持酶名/底物模糊查询与 kcat、Km 区间筛选；图谱视图仅在命中结果小于 20 条时开放）
记录: 300000
酶: 11
底物: 33
命中: 300000
| Enzyme | Mutation | Substrate | Product | kcat (1/s) | Km (mM) | pH | Temp | DOI | 详情 |
|---|---|---|---|---|---|---|---|---|---|
| CYP102A1 | A82I | Lauric acid | 12-Hydroxydodecanoic acid | 45 | 320000 | - | - | 10.1016/j.jmb.2007.08.015 |
展开ID：299980
protein_id：P14779
mutations：A82I
kcat/Km：0.000140625
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "A82I", "Km_mM": 320000.0, "kcat_1s_1": 45.0, "Kcat_dev_Km": 0.000140625, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": NaN, "Temp": NaN, "DOI": "10.1016/j.jmb.2007.08.015", "Source": "Bacillus megaterium"}
|
| CYP102A1 | WT | Arachidonic Acid | - | 285 | 4700 | 7.4 | 30.0 | 10.1021/bi010716m |
展开ID：299979
protein_id：P14779
mutations：WT
kcat/Km：0.0606383
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O product_smiles
- raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "WT", "Km_mM": 4700.0, "kcat_1s_1": 285.0, "Kcat_dev_Km": 0.06063829787234042, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Arachidonic Acid", "substrate_smiles": "CCCCCC=CCC=CCC=CCC=CCCCC(=O)O", "product": null, "product_smiles": null, "pH": 7.4, "Temp": 30.0, "DOI": "10.1021/bi010716m", "Source": "Bacillus megaterium"}
|
| CYP2A6 | K476E | coumarin | 7-hydroxycoumarin | 0.0085 | 1400 | 7.4 | 37.0 | 10.1074/jbc.M508171200 |
展开ID：299978
protein_id：P11509
mutations：K476E
kcat/Km：0.4
Vmax：-
relative_activity：0.0816327
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR real_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKEVGFATIPRNYTMSFLPR substrate_smiles
C1=CC=C2C(=C1)C=CC(=O)O2 product_smiles
C1=CC(=CC2=C1C=CC(=O)O2)O raw_row_json
{"enzyme-name": "CYP2A6", "protein-id": "P11509", "wt_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "real_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKEVGFATIPRNYTMSFLPR", "mutations": "K476E", "Km_mM": 1400.0, "kcat_1s_1": 0.0085, "Kcat_dev_Km": 0.4, "Vmax": NaN, "relative_activity": 0.08163265306122448, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "coumarin", "substrate_smiles": "C1=CC=C2C(=C1)C=CC(=O)O2", "product": "7-hydroxycoumarin", "product_smiles": "C1=CC(=CC2=C1C=CC(=O)O2)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.1074/jbc.M508171200", "Source": "Homo sapiens"}
|
| CYP2B11dH | modified type | 7-Ethoxy-4-trifluoromethylcoumarin | 7-(1-hydroxyethoxy)-4-trifluoromethylcoumarin | 0.216667 | 18000 | 7.6 | 37.0 | 10.1016/j.abb.2006.12.021 |
展开ID：299977
protein_id：P24460
mutations：modified type
kcat/Km：0.68
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：-
wt_sequence
MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH real_sequence
/ substrate_smiles
CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F product_smiles
CC(O)OC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F raw_row_json
{"enzyme-name": "CYP2B11dH", "protein-id": "P24460", "wt_sequence": "MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH", "real_sequence": "/", "mutations": "modified type", "Km_mM": 18000.0, "kcat_1s_1": 0.216666667, "Kcat_dev_Km": 0.68, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "7-Ethoxy-4-trifluoromethylcoumarin", "substrate_smiles": "CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F", "product": "7-(1-hydroxyethoxy)-4-trifluoromethylcoumarin", "product_smiles": "CC(O)OC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F", "pH": 7.6, "Temp": 37.0, "DOI": "10.1016/j.abb.2006.12.021", "Source": null}
|
| CYP1A2 | D348N | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | 2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | 0.483333 | 62000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299976
protein_id：P05177
mutations：D348N
kcat/Km：0.46
Vmax：-
relative_activity：2.875
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N product_smiles
CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "D348N", "Km_mM": 62000.0, "kcat_1s_1": 0.483333333, "Kcat_dev_Km": 0.46, "Vmax": NaN, "relative_activity": 2.875, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine", "substrate_smiles": "CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N", "product": "2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine", "product_smiles": "CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP1A2 | C406Y | Phenacetin | N-[4-(1-hydroxyethoxy)phenyl]acetamide | 0.02 | 62000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299975
protein_id：P05177
mutations：C406Y
kcat/Km：0.019
Vmax：-
relative_activity：0.327586
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CCOC1=CC=C(C=C1)NC(=O)C product_smiles
CC(O)OC1=CC=C(C=C1)NC(=O)C raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "C406Y", "Km_mM": 62000.0, "kcat_1s_1": 0.02, "Kcat_dev_Km": 0.019, "Vmax": NaN, "relative_activity": 0.3275862068965517, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Phenacetin", "substrate_smiles": "CCOC1=CC=C(C=C1)NC(=O)C", "product": "N-[4-(1-hydroxyethoxy)phenyl]acetamide", "product_smiles": "CC(O)OC1=CC=C(C=C1)NC(=O)C", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP102A1 | I401E | Lauric acid | 12-Hydroxydodecanoic acid | 15 | 23000 | - | - | 10.1039/c1cs15192d |
展开ID：299974
protein_id：P14779
mutations：I401E
kcat/Km：0.000652174
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "I401E", "Km_mM": 23000.0, "kcat_1s_1": 15.0, "Kcat_dev_Km": 0.0006521739130434783, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": NaN, "Temp": NaN, "DOI": "10.1039/c1cs15192d", "Source": "Bacillus megaterium"}
|
| CYP71A10 | WT | Diuron | N'-(3,4-Dichlorophenyl)-N-(hydroxymethyl)-N-methylurea | 0.00666667 | 1500 | - | - | 10.1073/pnas.96.4.1750 |
展开ID：299973
protein_id：O48918
mutations：WT
kcat/Km：4.44444e-06
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Glycine max
wt_sequence
MALLSSVLKQLPHELSSTHYLTVFFCIFLILLQLIRRNKYNLPPSPPKIPIIGNLHQLGTLPHRSFHALSHKYGPLMMLQLGQIPTLVVSSADVAREIIKTHDVVFSNRRQPTAAKIFGYGCKDVAFVYYREEWRQKIKTCKVELMSLKKVRLFHSIRQEVVTELVEAIGEACGSERPCVNLTEMLMAASNDIVSRCVLGRKCDDACGGSGSSSFAALGRKIMRLLSAFSVGDFFPSLGWVDYLTGLIPEMKTTFLAVDAFLDEVIAEHESSNKKNDDFLGILLQLQECGRLDFQLDRDNLKAILVDMIIGGSDTTSTTLEWTFAEFLRNPNTMKKAQEEVRRVVGINSKAVLDENCVNQMNYLKCVVKETLRLHPPLPLLIARETSSSVKLRGYDIPAKTMVFINAWAIQRDPELWDDPEEFIPERFETSQVDLNGQDFQLIPFGIGRRGCPAMSFGLASTEYVLANLLYWFNWNMSESGRILMHNIDMSETNGLTVSKKVPLHLEPEPYKT real_sequence
/ substrate_smiles
CN(C)C(=O)NC1=CC(=C(C=C1)Cl)Cl product_smiles
CN(CO)C(=O)NC1=CC(=C(C=C1)Cl)Cl raw_row_json
{"enzyme-name": "CYP71A10", "protein-id": "O48918", "wt_sequence": "MALLSSVLKQLPHELSSTHYLTVFFCIFLILLQLIRRNKYNLPPSPPKIPIIGNLHQLGTLPHRSFHALSHKYGPLMMLQLGQIPTLVVSSADVAREIIKTHDVVFSNRRQPTAAKIFGYGCKDVAFVYYREEWRQKIKTCKVELMSLKKVRLFHSIRQEVVTELVEAIGEACGSERPCVNLTEMLMAASNDIVSRCVLGRKCDDACGGSGSSSFAALGRKIMRLLSAFSVGDFFPSLGWVDYLTGLIPEMKTTFLAVDAFLDEVIAEHESSNKKNDDFLGILLQLQECGRLDFQLDRDNLKAILVDMIIGGSDTTSTTLEWTFAEFLRNPNTMKKAQEEVRRVVGINSKAVLDENCVNQMNYLKCVVKETLRLHPPLPLLIARETSSSVKLRGYDIPAKTMVFINAWAIQRDPELWDDPEEFIPERFETSQVDLNGQDFQLIPFGIGRRGCPAMSFGLASTEYVLANLLYWFNWNMSESGRILMHNIDMSETNGLTVSKKVPLHLEPEPYKT", "real_sequence": "/", "mutations": "WT", "Km_mM": 1500.0, "kcat_1s_1": 0.006666667, "Kcat_dev_Km": 4.444444666666667e-06, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Diuron", "substrate_smiles": "CN(C)C(=O)NC1=CC(=C(C=C1)Cl)Cl", "product": "N'-(3,4-Dichlorophenyl)-N-(hydroxymethyl)-N-methylurea", "product_smiles": "CN(CO)C(=O)NC1=CC(=C(C=C1)Cl)Cl", "pH": NaN, "Temp": NaN, "DOI": "10.1073/pnas.96.4.1750", "Source": "Glycine max"}
|
| CYP1A2 | I386F | 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline | 2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline | 0.3 | 46000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299972
protein_id：P05177
mutations：I386F
kcat/Km：0.38
Vmax：-
relative_activity：1.9
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N product_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "I386F", "Km_mM": 46000.0, "kcat_1s_1": 0.3, "Kcat_dev_Km": 0.38, "Vmax": NaN, "relative_activity": 1.9, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline", "substrate_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N", "product": "2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline", "product_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP2C8 | D349Y+V237A | Arachidonic Acid | 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid | 0.0933333 | 50600 | 7.4 | 37.0 | 10.3390/pharmaceutics13091429 |
展开ID：299971
protein_id：P10632
mutations：D349Y+V237A
kcat/Km：0.11
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV real_sequence
- substrate_smiles
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O product_smiles
CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)O raw_row_json
{"enzyme-name": "CYP2C8", "protein-id": "P10632", "wt_sequence": "MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV", "real_sequence": null, "mutations": "D349Y+V237A", "Km_mM": 50600.0, "kcat_1s_1": 0.093333333, "Kcat_dev_Km": 0.11, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Arachidonic Acid", "substrate_smiles": "CCCCCC=CCC=CCC=CCC=CCCCC(=O)O", "product": "14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid", "product_smiles": "CCCCCC1C(O1)CC=CCC=CCC=CCCCC(=O)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.3390/pharmaceutics13091429", "Source": "Homo sapiens"}
|
| CYP2B11 | WT | 7-benzyloxyresorufin | - | 0.045 | - | 7.6 | 37.0 | 10.1016/j.abb.2006.12.021 |
展开ID：299970
protein_id：P24460
mutations：WT
kcat/Km：-
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：-
wt_sequence
MELSVLLLLALLTGLLLLMARGHPKAYGHLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGC real_sequence
- substrate_smiles
C1=CC=C(C=C1)COC2=CC3=C(C=C2)N=C4C=CC(=O)C=C4O3 product_smiles
C1=CC=C(C=C1)C(O)OC2=CC3=C(C=C2)N=C4C=CC(=O)C=C4O3 raw_row_json
{"enzyme-name": "CYP2B11", "protein-id": "P24460", "wt_sequence": "MELSVLLLLALLTGLLLLMARGHPKAYGHLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGC", "real_sequence": null, "mutations": "WT", "Km_mM": NaN, "kcat_1s_1": 0.045, "Kcat_dev_Km": "/", "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "7-benzyloxyresorufin", "substrate_smiles": "C1=CC=C(C=C1)COC2=CC3=C(C=C2)N=C4C=CC(=O)C=C4O3", "product": null, "product_smiles": "C1=CC=C(C=C1)C(O)OC2=CC3=C(C=C2)N=C4C=CC(=O)C=C4O3", "pH": 7.6, "Temp": 37.0, "DOI": "10.1016/j.abb.2006.12.021", "Source": null}
|
| CYP2C8 | I244V | Arachidonic Acid | 11,12-Epoxyeicosatrienoic acid | 0.255 | 7000 | 7.4 | 37.0 | 10.3390/ijms24098032 |
展开ID：299969
protein_id：P10632
mutations：I244V
kcat/Km：2.19
Vmax：-
relative_activity：1.33
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV real_sequence
- substrate_smiles
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O product_smiles
CCCCCC=CCC1C(O1)CC=CCC=CCCCC(=O)O raw_row_json
{"enzyme-name": "CYP2C8", "protein-id": "P10632", "wt_sequence": "MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV", "real_sequence": null, "mutations": "I244V", "Km_mM": 7000.0, "kcat_1s_1": 0.255, "Kcat_dev_Km": 2.19, "Vmax": NaN, "relative_activity": 1.33, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Arachidonic Acid", "substrate_smiles": "CCCCCC=CCC=CCC=CCC=CCCCC(=O)O", "product": "11,12-Epoxyeicosatrienoic acid", "product_smiles": "CCCCCC=CCC1C(O1)CC=CCC=CCCCC(=O)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.3390/ijms24098032", "Source": "Homo sapiens"}
|
| CYP102A1 | I401P | Lauric acid | 12-Hydroxydodecanoic acid | 71 | 21000 | - | - | 10.1039/c1cs15192d |
展开ID：299968
protein_id：P14779
mutations：I401P
kcat/Km：0.00338095
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "I401P", "Km_mM": 21000.0, "kcat_1s_1": 71.0, "Kcat_dev_Km": 0.0033809523809523808, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": NaN, "Temp": NaN, "DOI": "10.1039/c1cs15192d", "Source": "Bacillus megaterium"}
|
| CYP102A1 | L86E | Lauric acid | 12-Hydroxydodecanoic acid | 67 | 32000 | - | - | 10.1039/c1cs15192d |
展开ID：299967
protein_id：P14779
mutations：L86E
kcat/Km：0.00209375
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "L86E", "Km_mM": 32000.0, "kcat_1s_1": 67.0, "Kcat_dev_Km": 0.00209375, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": NaN, "Temp": NaN, "DOI": "10.1039/c1cs15192d", "Source": "Bacillus megaterium"}
|
| CYP2C8 | D349Y | Arachidonic Acid | 11,12-Epoxyeicosatrienoic acid | 0.045 | 17200 | 7.4 | 37.0 | 10.3390/pharmaceutics13091429 |
展开ID：299966
protein_id：P10632
mutations：D349Y
kcat/Km：0.16
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV real_sequence
- substrate_smiles
CCCCCC=CCC=CCC=CCC=CCCCC(=O)O product_smiles
CCCCCC=CCC1C(O1)CC=CCC=CCCCC(=O)O raw_row_json
{"enzyme-name": "CYP2C8", "protein-id": "P10632", "wt_sequence": "MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV", "real_sequence": null, "mutations": "D349Y", "Km_mM": 17200.0, "kcat_1s_1": 0.045, "Kcat_dev_Km": 0.16, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Arachidonic Acid", "substrate_smiles": "CCCCCC=CCC=CCC=CCC=CCCCC(=O)O", "product": "11,12-Epoxyeicosatrienoic acid", "product_smiles": "CCCCCC=CCC1C(O1)CC=CCC=CCCCC(=O)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.3390/pharmaceutics13091429", "Source": "Homo sapiens"}
|
| CYP2B11dH | V183L | Testosterone | 16beta-hydroxytestosterone | - | - | 7.6 | 37.0 | 10.1016/j.abb.2006.12.021 |
展开ID：299965
protein_id：P24460
mutations：V183L
kcat/Km：-
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：-
wt_sequence
MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH real_sequence
- substrate_smiles
CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C product_smiles
CC12CCC(=O)C=C1CCC3C2CCC4(C3CC(C4O)O)C raw_row_json
{"enzyme-name": "CYP2B11dH", "protein-id": "P24460", "wt_sequence": "MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH", "real_sequence": null, "mutations": "V183L", "Km_mM": NaN, "kcat_1s_1": NaN, "Kcat_dev_Km": "/", "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Testosterone", "substrate_smiles": "CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C", "product": "16beta-hydroxytestosterone", "product_smiles": "CC12CCC(=O)C=C1CCC3C2CCC4(C3CC(C4O)O)C", "pH": 7.6, "Temp": 37.0, "DOI": "10.1016/j.abb.2006.12.021", "Source": null}
|
| CYP1A2 | C406Y | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | 2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | 0.433333 | 66000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299964
protein_id：P05177
mutations：C406Y
kcat/Km：0.39
Vmax：-
relative_activity：2.4375
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N product_smiles
CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "C406Y", "Km_mM": 66000.0, "kcat_1s_1": 0.433333333, "Kcat_dev_Km": 0.39, "Vmax": NaN, "relative_activity": 2.4375, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine", "substrate_smiles": "CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N", "product": "2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine", "product_smiles": "CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP2B11dH | F202L | Testosterone | 16beta-hydroxytestosterone | - | - | 7.6 | 37.0 | 10.1016/j.abb.2006.12.021 |
展开ID：299963
protein_id：P24460
mutations：F202L
kcat/Km：-
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：-
wt_sequence
MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH real_sequence
- substrate_smiles
CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C product_smiles
CC12CCC(=O)C=C1CCC3C2CCC4(C3CC(C4O)O)C raw_row_json
{"enzyme-name": "CYP2B11dH", "protein-id": "P24460", "wt_sequence": "MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH", "real_sequence": null, "mutations": "F202L", "Km_mM": NaN, "kcat_1s_1": NaN, "Kcat_dev_Km": "/", "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Testosterone", "substrate_smiles": "CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C", "product": "16beta-hydroxytestosterone", "product_smiles": "CC12CCC(=O)C=C1CCC3C2CCC4(C3CC(C4O)O)C", "pH": 7.6, "Temp": 37.0, "DOI": "10.1016/j.abb.2006.12.021", "Source": null}
|
| CYP1A2 | C406Y | 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline | 2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline | 0.126667 | 20000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299962
protein_id：P05177
mutations：C406Y
kcat/Km：0.38
Vmax：-
relative_activity：1.9
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N product_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "C406Y", "Km_mM": 20000.0, "kcat_1s_1": 0.126666667, "Kcat_dev_Km": 0.38, "Vmax": NaN, "relative_activity": 1.9, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline", "substrate_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N", "product": "2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline", "product_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
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| CYP1A2 | E225N+Q258H+G437D | 2-amino-3-methylimidazolo(4,5-f)quinoline | 2-Hydroxyamino-3-methylimidazolo(4,5-f)quinoline | 0.286667 | 34000 | 7.4 | 37.0 | 10.1021/bi035593f |
展开ID：299961
protein_id：P05177
mutations：E225N+Q258H+G437D
kcat/Km：0.51
Vmax：-
relative_activity：1.88889
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHNFVETASSGNPLDFFPILRYLPNPALQRFKAFNHRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADDTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN substrate_smiles
CN1C2=C(C3=C(C=C2)N=CC=C3)N=C1N product_smiles
CN1C2=C(C3=C(C=C2)N=CC=C3)N=C1NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHNFVETASSGNPLDFFPILRYLPNPALQRFKAFNHRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADDTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "mutations": "E225N+Q258H+G437D", "Km_mM": 34000.0, "kcat_1s_1": 0.286666667, "Kcat_dev_Km": 0.51, "Vmax": NaN, "relative_activity": 1.8888888888888888, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3-methylimidazolo(4,5-f)quinoline", "substrate_smiles": "CN1C2=C(C3=C(C=C2)N=CC=C3)N=C1N", "product": "2-Hydroxyamino-3-methylimidazolo(4,5-f)quinoline", "product_smiles": "CN1C2=C(C3=C(C=C2)N=CC=C3)N=C1NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1021/bi035593f", "Source": "Homo sapiens"}
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