数据库系统
切换到图谱视图酶反应数据库检索（支持酶名/底物模糊查询与 kcat、Km 区间筛选；图谱视图仅在命中结果小于 20 条时开放）
记录: 300000
酶: 11
底物: 33
命中: 300000
| Enzyme | Mutation | Substrate | Product | kcat (1/s) | Km (mM) | pH | Temp | DOI | 详情 |
|---|---|---|---|---|---|---|---|---|---|
| CYP102A1 | T268A+F393H | Lauric acid | 12-Hydroxydodecanoic acid | 22 | 85000 | 7.4 | 15.0 | 10.1016/j.jinorgbio.2005.11.020 |
展开ID：299800
protein_id：P14779
mutations：T268A+F393H
kcat/Km：0.000258824
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "T268A+F393H", "Km_mM": 85000.0, "kcat_1s_1": 22.0, "Kcat_dev_Km": 0.0002588235294117647, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": 7.4, "Temp": 15.0, "DOI": "10.1016/j.jinorgbio.2005.11.020", "Source": "Bacillus megaterium"}
|
| CYP1A2 | C406Y | 2-amino-3,5-dimethylimidazo(4,5-f)quinoline | 2-Hydroxyamino-3,5-dimethylimidazo(4,5-f)quinoline | 0.075 | 14000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299799
protein_id：P05177
mutations：C406Y
kcat/Km：0.31
Vmax：-
relative_activity：2.58333
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)N product_smiles
CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "C406Y", "Km_mM": 14000.0, "kcat_1s_1": 0.075, "Kcat_dev_Km": 0.31, "Vmax": NaN, "relative_activity": 2.5833333333333335, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,5-dimethylimidazo(4,5-f)quinoline", "substrate_smiles": "CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)N", "product": "2-Hydroxyamino-3,5-dimethylimidazo(4,5-f)quinoline", "product_smiles": "CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP1A2 | WT | 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline | 2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline | 0.09 | 27000 | 7.4 | 37.0 | 10.1021/bi035593f |
展开ID：299798
protein_id：P05177
mutations：WT
kcat/Km：0.2
Vmax：-
relative_activity：1
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
/ substrate_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N product_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": "/", "mutations": "WT", "Km_mM": 27000.0, "kcat_1s_1": 0.09, "Kcat_dev_Km": 0.2, "Vmax": NaN, "relative_activity": 1, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline", "substrate_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N", "product": "2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline", "product_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1021/bi035593f", "Source": "Homo sapiens"}
|
| CYP1A2 | E225N | 2-amino-6-methyldipyrido(1,2-a:3',2'-d)imidazole | 2-Hydroxyamino-6-methyldipyrido(1,2-a:3',2'-d)imidazole | 0.333333 | 17000 | 7.4 | 37.0 | 10.1021/bi035593f |
展开ID：299797
protein_id：P05177
mutations：E225N
kcat/Km：1.1
Vmax：-
relative_activity：0.916667
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHNFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN substrate_smiles
CC1=CC=CN2C1=NC3=C2N=C(C=C3)N product_smiles
CC1=CC=CN2C1=NC3=C2N=C(C=C3)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHNFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "mutations": "E225N", "Km_mM": 17000.0, "kcat_1s_1": 0.333333333, "Kcat_dev_Km": 1.1, "Vmax": NaN, "relative_activity": 0.9166666666666667, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-6-methyldipyrido(1,2-a:3',2'-d)imidazole", "substrate_smiles": "CC1=CC=CN2C1=NC3=C2N=C(C=C3)N", "product": "2-Hydroxyamino-6-methyldipyrido(1,2-a:3',2'-d)imidazole", "product_smiles": "CC1=CC=CN2C1=NC3=C2N=C(C=C3)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1021/bi035593f", "Source": "Homo sapiens"}
|
| CYP105A1 | R73V+R84F | 25-hydroxyvitamin D3 | 1-alpha,25-hydroxyvitamin D3 | 0.000783333 | 1600 | 7.4 | 30.0 | 10.1021/bi801222d |
展开ID：299796
protein_id：P18326
mutations：R73V+R84F
kcat/Km：0.029
Vmax：-
relative_activity：49
activity_U/mg：-
conversion_rate：-
yield：-
Source：Streptomyces griseolus
wt_sequence
MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW real_sequence
MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNVTDDNFPATSPFFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW substrate_smiles
CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C product_smiles
CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C raw_row_json
{"enzyme-name": "CYP105A1", "protein-id": "P18326", "wt_sequence": "MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW", "real_sequence": "MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNVTDDNFPATSPFFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW", "mutations": "R73V+R84F", "Km_mM": 1600.0, "kcat_1s_1": 0.000783333, "Kcat_dev_Km": 0.029, "Vmax": NaN, "relative_activity": 49, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "25-hydroxyvitamin D3", "substrate_smiles": "CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C", "product": "1-alpha,25-hydroxyvitamin D3", "product_smiles": "CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C", "pH": 7.4, "Temp": 30.0, "DOI": "10.1021/bi801222d", "Source": "Streptomyces griseolus "}
|
| CYP102A1 | F87A | 12-(4-Nitrophenoxy)dodecanoic acid | 12-hydroxy-(4-Nitrophenoxy)dodecanoic acid | 6.2 | 8100 | 8.2 | 25.0 | 10.1016/s0167-4838(00)00268-5 |
展开ID：299795
protein_id：P14779
mutations：F87A
kcat/Km：0.000765432
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG substrate_smiles
C1=CC(=CC=C1[N+](=O)[O-])OCCCCCCCCCCCC(=O)O product_smiles
C1=CC(=CC=C1[N+](=O)[O-])OC(O)CCCCCCCCCCC(=O)O raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "mutations": "F87A", "Km_mM": 8100.0, "kcat_1s_1": 6.2, "Kcat_dev_Km": 0.0007654320987654322, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "12-(4-Nitrophenoxy)dodecanoic acid", "substrate_smiles": "C1=CC(=CC=C1[N+](=O)[O-])OCCCCCCCCCCCC(=O)O", "product": "12-hydroxy-(4-Nitrophenoxy)dodecanoic acid", "product_smiles": "C1=CC(=CC=C1[N+](=O)[O-])OC(O)CCCCCCCCCCC(=O)O", "pH": 8.2, "Temp": 25.0, "DOI": "10.1016/s0167-4838(00)00268-5", "Source": "Bacillus megaterium"}
|
| CYP105A1 | WT | 1-alpha-hydroxyvitamin D3 | 1-alpha,25-hydroxyvitamin D3 | 0.000126667 | 10100 | 7.4 | 30.0 | 10.1021/bi801222d |
展开ID：299794
protein_id：P18326
mutations：WT
kcat/Km：0.00075
Vmax：-
relative_activity：1
activity_U/mg：-
conversion_rate：-
yield：-
Source：Streptomyces griseolus
wt_sequence
MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW real_sequence
/ substrate_smiles
CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C product_smiles
CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C raw_row_json
{"enzyme-name": "CYP105A1", "protein-id": "P18326", "wt_sequence": "MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRPGTTIQGVNELPVTW", "real_sequence": "/", "mutations": "WT", "Km_mM": 10100.0, "kcat_1s_1": 0.000126667, "Kcat_dev_Km": 0.00075, "Vmax": NaN, "relative_activity": 1, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "1-alpha-hydroxyvitamin D3", "substrate_smiles": "CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C", "product": "1-alpha,25-hydroxyvitamin D3", "product_smiles": "CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C", "pH": 7.4, "Temp": 30.0, "DOI": "10.1021/bi801222d", "Source": "Streptomyces griseolus "}
|
| CYP71A10 | WT | Chlortoluron | N'-[3-Chloro-4-(hydroxymethyl)phenyl]-N,N-dimethylurea | 0.0116667 | 1000 | - | - | 10.1073/pnas.96.4.1750 |
展开ID：299793
protein_id：O48918
mutations：WT
kcat/Km：1.16667e-05
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Glycine max
wt_sequence
MALLSSVLKQLPHELSSTHYLTVFFCIFLILLQLIRRNKYNLPPSPPKIPIIGNLHQLGTLPHRSFHALSHKYGPLMMLQLGQIPTLVVSSADVAREIIKTHDVVFSNRRQPTAAKIFGYGCKDVAFVYYREEWRQKIKTCKVELMSLKKVRLFHSIRQEVVTELVEAIGEACGSERPCVNLTEMLMAASNDIVSRCVLGRKCDDACGGSGSSSFAALGRKIMRLLSAFSVGDFFPSLGWVDYLTGLIPEMKTTFLAVDAFLDEVIAEHESSNKKNDDFLGILLQLQECGRLDFQLDRDNLKAILVDMIIGGSDTTSTTLEWTFAEFLRNPNTMKKAQEEVRRVVGINSKAVLDENCVNQMNYLKCVVKETLRLHPPLPLLIARETSSSVKLRGYDIPAKTMVFINAWAIQRDPELWDDPEEFIPERFETSQVDLNGQDFQLIPFGIGRRGCPAMSFGLASTEYVLANLLYWFNWNMSESGRILMHNIDMSETNGLTVSKKVPLHLEPEPYKT real_sequence
/ substrate_smiles
CC1=C(C=C(C=C1)NC(=O)N(C)C)Cl product_smiles
C(O)C1=C(C=C(C=C1)NC(=O)N(C)C)Cl raw_row_json
{"enzyme-name": "CYP71A10", "protein-id": "O48918", "wt_sequence": "MALLSSVLKQLPHELSSTHYLTVFFCIFLILLQLIRRNKYNLPPSPPKIPIIGNLHQLGTLPHRSFHALSHKYGPLMMLQLGQIPTLVVSSADVAREIIKTHDVVFSNRRQPTAAKIFGYGCKDVAFVYYREEWRQKIKTCKVELMSLKKVRLFHSIRQEVVTELVEAIGEACGSERPCVNLTEMLMAASNDIVSRCVLGRKCDDACGGSGSSSFAALGRKIMRLLSAFSVGDFFPSLGWVDYLTGLIPEMKTTFLAVDAFLDEVIAEHESSNKKNDDFLGILLQLQECGRLDFQLDRDNLKAILVDMIIGGSDTTSTTLEWTFAEFLRNPNTMKKAQEEVRRVVGINSKAVLDENCVNQMNYLKCVVKETLRLHPPLPLLIARETSSSVKLRGYDIPAKTMVFINAWAIQRDPELWDDPEEFIPERFETSQVDLNGQDFQLIPFGIGRRGCPAMSFGLASTEYVLANLLYWFNWNMSESGRILMHNIDMSETNGLTVSKKVPLHLEPEPYKT", "real_sequence": "/", "mutations": "WT", "Km_mM": 1000.0, "kcat_1s_1": 0.011666667, "Kcat_dev_Km": 1.1666667000000001e-05, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Chlortoluron", "substrate_smiles": "CC1=C(C=C(C=C1)NC(=O)N(C)C)Cl", "product": "N'-[3-Chloro-4-(hydroxymethyl)phenyl]-N,N-dimethylurea", "product_smiles": "C(O)C1=C(C=C(C=C1)NC(=O)N(C)C)Cl", "pH": NaN, "Temp": NaN, "DOI": "10.1073/pnas.96.4.1750", "Source": "Glycine max"}
|
| CYP1A2 | E225N+Q258K+G437D | 2-amino-3,5-dimethylimidazo(4,5-f)quinoline | 2-Hydroxyamino-3,5-dimethylimidazo(4,5-f)quinoline | 0.0866667 | 16000 | 7.4 | 37.0 | 10.1021/bi035593f |
展开ID：299792
protein_id：P05177
mutations：E225N+Q258K+G437D
kcat/Km：0.33
Vmax：-
relative_activity：2.75
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)N product_smiles
CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "E225N+Q258K+G437D", "Km_mM": 16000.0, "kcat_1s_1": 0.086666667, "Kcat_dev_Km": 0.33, "Vmax": NaN, "relative_activity": 2.7500000000000004, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,5-dimethylimidazo(4,5-f)quinoline", "substrate_smiles": "CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)N", "product": "2-Hydroxyamino-3,5-dimethylimidazo(4,5-f)quinoline", "product_smiles": "CC1=CC2=C(C3=C1N=CC=C3)N=C(N2C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1021/bi035593f", "Source": "Homo sapiens"}
|
| CYP1A2 | D348N | Phenacetin | N-[4-(1-hydroxyethoxy)phenyl]acetamide | 0.015 | 18000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299791
protein_id：P05177
mutations：D348N
kcat/Km：0.051
Vmax：-
relative_activity：0.87931
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CCOC1=CC=C(C=C1)NC(=O)C product_smiles
CC(O)OC1=CC=C(C=C1)NC(=O)C raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "D348N", "Km_mM": 18000.0, "kcat_1s_1": 0.015, "Kcat_dev_Km": 0.051, "Vmax": NaN, "relative_activity": 0.8793103448275861, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Phenacetin", "substrate_smiles": "CCOC1=CC=C(C=C1)NC(=O)C", "product": "N-[4-(1-hydroxyethoxy)phenyl]acetamide", "product_smiles": "CC(O)OC1=CC=C(C=C1)NC(=O)C", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP2B11dH | V183L+I209A | 7-Ethoxy-4-trifluoromethylcoumarin | 7-(1-hydroxyethoxy)-4-trifluoromethylcoumarin | 0.0366667 | 2000 | 7.6 | 37.0 | 10.1016/j.abb.2006.12.021 |
展开ID：299790
protein_id：P24460
mutations：V183L+I209A
kcat/Km：1.1
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：-
wt_sequence
MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH real_sequence
- substrate_smiles
CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F product_smiles
CC(O)OC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F raw_row_json
{"enzyme-name": "CYP2B11dH", "protein-id": "P24460", "wt_sequence": "MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH", "real_sequence": null, "mutations": "V183L+I209A", "Km_mM": 2000.0, "kcat_1s_1": 0.036666667, "Kcat_dev_Km": 1.1, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "7-Ethoxy-4-trifluoromethylcoumarin", "substrate_smiles": "CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F", "product": "7-(1-hydroxyethoxy)-4-trifluoromethylcoumarin", "product_smiles": "CC(O)OC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F", "pH": 7.6, "Temp": 37.0, "DOI": "10.1016/j.abb.2006.12.021", "Source": null}
|
| CYP102A1 | WT | Lauric acid | 12-Hydroxydodecanoic acid | 85 | 280000 | 7.4 | 30.0 | 10.1021/bi049163g |
展开ID：299789
protein_id：P14779
mutations：WT
kcat/Km：0.000303571
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：Bacillus megaterium
wt_sequence
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG real_sequence
- substrate_smiles
CCCCCCCCCCCC(=O)O product_smiles
C(CCCCCC(=O)O)CCCCCO raw_row_json
{"enzyme-name": "CYP102A1", "protein-id": "P14779", "wt_sequence": "MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG", "real_sequence": null, "mutations": "WT", "Km_mM": 280000.0, "kcat_1s_1": 85.0, "Kcat_dev_Km": 0.00030357142857142855, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "Lauric acid", "substrate_smiles": "CCCCCCCCCCCC(=O)O", "product": "12-Hydroxydodecanoic acid", "product_smiles": "C(CCCCCC(=O)O)CCCCCO", "pH": 7.4, "Temp": 30.0, "DOI": "10.1021/bi049163g", "Source": "Bacillus megaterium"}
|
| CYP2B11dH | F202L | 7-Ethoxy-4-trifluoromethylcoumarin | 7-(1-hydroxyethoxy)-4-trifluoromethylcoumarin | 0.25 | 45000 | 7.6 | 37.0 | 10.1016/j.abb.2006.12.021 |
展开ID：299788
protein_id：P24460
mutations：F202L
kcat/Km：0.29
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：-
wt_sequence
MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH real_sequence
- substrate_smiles
CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F product_smiles
CC(O)OC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F raw_row_json
{"enzyme-name": "CYP2B11dH", "protein-id": "P24460", "wt_sequence": "MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH", "real_sequence": null, "mutations": "F202L", "Km_mM": 45000.0, "kcat_1s_1": 0.25, "Kcat_dev_Km": 0.29, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "7-Ethoxy-4-trifluoromethylcoumarin", "substrate_smiles": "CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F", "product": "7-(1-hydroxyethoxy)-4-trifluoromethylcoumarin", "product_smiles": "CC(O)OC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F", "pH": 7.6, "Temp": 37.0, "DOI": "10.1016/j.abb.2006.12.021", "Source": null}
|
| CYP1A2 | I386F | 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline | 2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline | 0.3 | 46000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299787
protein_id：P05177
mutations：I386F
kcat/Km：0.38
Vmax：-
relative_activity：1.9
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N product_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "I386F", "Km_mM": 46000.0, "kcat_1s_1": 0.3, "Kcat_dev_Km": 0.38, "Vmax": NaN, "relative_activity": 1.9, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline", "substrate_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N", "product": "2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline", "product_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP2A6 | I16F | coumarin | 7-hydroxycoumarin | 0.218333 | 4100 | 7.4 | 37.0 | 10.1074/jbc.M508171200 |
展开ID：299786
protein_id：P11509
mutations：I16F
kcat/Km：3.2
Vmax：-
relative_activity：0.653061
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR real_sequence
MLASGMLLVALLVCLTFMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR substrate_smiles
C1=CC=C2C(=C1)C=CC(=O)O2 product_smiles
C1=CC(=CC2=C1C=CC(=O)O2)O raw_row_json
{"enzyme-name": "CYP2A6", "protein-id": "P11509", "wt_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "real_sequence": "MLASGMLLVALLVCLTFMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "mutations": "I16F", "Km_mM": 4100.0, "kcat_1s_1": 0.218333333, "Kcat_dev_Km": 3.2, "Vmax": NaN, "relative_activity": 0.6530612244897959, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "coumarin", "substrate_smiles": "C1=CC=C2C(=C1)C=CC(=O)O2", "product": "7-hydroxycoumarin", "product_smiles": "C1=CC(=CC2=C1C=CC(=O)O2)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.1074/jbc.M508171200", "Source": "Homo sapiens"}
|
| CYP1A2 | D348N | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | 2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | 0.483333 | 62000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299785
protein_id：P05177
mutations：D348N
kcat/Km：0.46
Vmax：-
relative_activity：2.875
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N product_smiles
CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "D348N", "Km_mM": 62000.0, "kcat_1s_1": 0.483333333, "Kcat_dev_Km": 0.46, "Vmax": NaN, "relative_activity": 2.875, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine", "substrate_smiles": "CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1N", "product": "2-Hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine", "product_smiles": "CN1C2=C(N=CC(=C2)C3=CC=CC=C3)N=C1NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP2A6 | V116M+F453Y | coumarin | 7-hydroxycoumarin | 0.0583333 | 2400 | 7.4 | 37.0 | 10.1074/jbc.M508171200 |
展开ID：299784
protein_id：P11509
mutations：V116M+F453Y
kcat/Km：1.5
Vmax：-
relative_activity：0.306122
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR real_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVMFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFYTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR substrate_smiles
C1=CC=C2C(=C1)C=CC(=O)O2 product_smiles
C1=CC(=CC2=C1C=CC(=O)O2)O raw_row_json
{"enzyme-name": "CYP2A6", "protein-id": "P11509", "wt_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "real_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVMFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFYTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "mutations": "V116M+F453Y", "Km_mM": 2400.0, "kcat_1s_1": 0.058333333, "Kcat_dev_Km": 1.5, "Vmax": NaN, "relative_activity": 0.3061224489795918, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "coumarin", "substrate_smiles": "C1=CC=C2C(=C1)C=CC(=O)O2", "product": "7-hydroxycoumarin", "product_smiles": "C1=CC(=CC2=C1C=CC(=O)O2)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.1074/jbc.M508171200", "Source": "Homo sapiens"}
|
| CYP1A2 | D348N | 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline | 2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline | 0.15 | 33000 | 7.4 | 37.0 | 10.1016/j.abb.2003.11.019 |
展开ID：299783
protein_id：P05177
mutations：D348N
kcat/Km：0.27
Vmax：-
relative_activity：1.35
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN real_sequence
- substrate_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N product_smiles
CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO raw_row_json
{"enzyme-name": "CYP1A2", "protein-id": "P05177", "wt_sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN", "real_sequence": null, "mutations": "D348N", "Km_mM": 33000.0, "kcat_1s_1": 0.15, "Kcat_dev_Km": 0.27, "Vmax": NaN, "relative_activity": 1.35, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline", "substrate_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)N", "product": "2-Hydroxyamino-3,8-dimethylimidazo[4,5-f]quinoxaline", "product_smiles": "CC1=CN=C2C=CC3=C(C2=N1)N=C(N3C)NO", "pH": 7.4, "Temp": 37.0, "DOI": "10.1016/j.abb.2003.11.019", "Source": "Homo sapiens"}
|
| CYP2A6 | N297S | coumarin | 7-hydroxycoumarin | 0.166667 | 7800 | 7.4 | 37.0 | 10.1074/jbc.M508171200 |
展开ID：299782
protein_id：P11509
mutations：N297S
kcat/Km：1.3
Vmax：-
relative_activity：0.265306
activity_U/mg：-
conversion_rate：-
yield：-
Source：Homo sapiens
wt_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR real_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNSFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR substrate_smiles
C1=CC=C2C(=C1)C=CC(=O)O2 product_smiles
C1=CC(=CC2=C1C=CC(=O)O2)O raw_row_json
{"enzyme-name": "CYP2A6", "protein-id": "P11509", "wt_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "real_sequence": "MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNSFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR", "mutations": "N297S", "Km_mM": 7800.0, "kcat_1s_1": 0.166666667, "Kcat_dev_Km": 1.3, "Vmax": NaN, "relative_activity": 0.2653061224489796, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "coumarin", "substrate_smiles": "C1=CC=C2C(=C1)C=CC(=O)O2", "product": "7-hydroxycoumarin", "product_smiles": "C1=CC(=CC2=C1C=CC(=O)O2)O", "pH": 7.4, "Temp": 37.0, "DOI": "10.1074/jbc.M508171200", "Source": "Homo sapiens"}
|
| CYP2B11dH | I209A | 7-Ethoxy-4-trifluoromethylcoumarin | 7-(1-hydroxyethoxy)-4-trifluoromethylcoumarin | 0.0266667 | 720 | 7.6 | 37.0 | 10.1016/j.abb.2006.12.021 |
展开ID：299781
protein_id：P24460
mutations：I209A
kcat/Km：2.2
Vmax：-
relative_activity：-
activity_U/mg：-
conversion_rate：-
yield：-
Source：-
wt_sequence
MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH real_sequence
- substrate_smiles
CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F product_smiles
CC(O)OC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F raw_row_json
{"enzyme-name": "CYP2B11dH", "protein-id": "P24460", "wt_sequence": "MALSVLLLLALLTGLLLLMARKKTSSKGKLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGCHHHH", "real_sequence": null, "mutations": "I209A", "Km_mM": 720.0, "kcat_1s_1": 0.026666667, "Kcat_dev_Km": 2.2, "Vmax": NaN, "relative_activity": null, "activity_U/mg": NaN, "conversion_rate": NaN, "yield": NaN, "substrate": "7-Ethoxy-4-trifluoromethylcoumarin", "substrate_smiles": "CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F", "product": "7-(1-hydroxyethoxy)-4-trifluoromethylcoumarin", "product_smiles": "CC(O)OC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F", "pH": 7.6, "Temp": 37.0, "DOI": "10.1016/j.abb.2006.12.021", "Source": null}
|